Bence-Jones proteins in urine are associated with which disease?

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Study for the Blood, Immune, and Hematologic Disorders Test. Improve your knowledge with our multiple choice questions. Each question provides hints and explanations. Prepare thoroughly for your exam!

Multiple Choice

Bence-Jones proteins in urine are associated with which disease?

Explanation:
Bence-Jones proteins are free immunoglobulin light chains produced in excess by malignant plasma cells. In multiple myeloma, a clonal plasma cell population overproduces identical light chains (kappa or lambda), which are small enough to be filtered by the kidneys and appear in urine as Bence-Jones proteins. Their presence in urine is a classic clue pointing to a plasma cell dyscrasia like multiple myeloma, and they can contribute to kidney injury in myeloma cast nephropathy. The other choices are myeloproliferative disorders not driven by monoclonal plasma cell production, so Bence-Jones proteins are not characteristic of them.

Bence-Jones proteins are free immunoglobulin light chains produced in excess by malignant plasma cells. In multiple myeloma, a clonal plasma cell population overproduces identical light chains (kappa or lambda), which are small enough to be filtered by the kidneys and appear in urine as Bence-Jones proteins. Their presence in urine is a classic clue pointing to a plasma cell dyscrasia like multiple myeloma, and they can contribute to kidney injury in myeloma cast nephropathy. The other choices are myeloproliferative disorders not driven by monoclonal plasma cell production, so Bence-Jones proteins are not characteristic of them.

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