In Chronic Lymphocytic Leukemia, the malignant clone is derived from which cell type?

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Study for the Blood, Immune, and Hematologic Disorders Test. Improve your knowledge with our multiple choice questions. Each question provides hints and explanations. Prepare thoroughly for your exam!

Multiple Choice

In Chronic Lymphocytic Leukemia, the malignant clone is derived from which cell type?

Explanation:
Chronic Lymphocytic Leukemia involves a malignant clone that originates from mature B lymphocytes. These abnormal B cells accumulate in the blood and bone marrow and often carry B-cell surface markers, reflecting their lineage. This differentiates CLL from conditions that arise from other cell types, such as T cells (seen in some T-cell leukemias), plasma cells (as in plasma cell myeloma), or erythrocytes (red blood cells, which are not leukocytes). Therefore, the malignant clone in CLL is derived from B lymphocytes.

Chronic Lymphocytic Leukemia involves a malignant clone that originates from mature B lymphocytes. These abnormal B cells accumulate in the blood and bone marrow and often carry B-cell surface markers, reflecting their lineage. This differentiates CLL from conditions that arise from other cell types, such as T cells (seen in some T-cell leukemias), plasma cells (as in plasma cell myeloma), or erythrocytes (red blood cells, which are not leukocytes). Therefore, the malignant clone in CLL is derived from B lymphocytes.

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