What does the CRABI acronym stand for in relation to Multiple Myeloma?

• A. Hypercalcemia, Renal dysfunction, Anemia, Bone damage, Reduced immune response
• B. Calcium deficiency, Renal failure, Anemia, Bone thinning, Immune suppression
• C. Hypercalcemia, Renal dysfunction, Anemia, Bone damage, Immunodeficiency
• D. Hyperkalemia, Renal dysfunction, Anemia, Bone damage, Reduced immune response

Answer: (A)

CRABI expands the classic myeloma findings to include immune vulnerability. It stands for hypercalcemia, renal dysfunction, anemia, bone damage, and immunodeficiency (reduced immune response). In multiple myeloma, malignant plasma cells drive bone resorption, releasing calcium (hypercalcemia); light chains and other factors injure the kidneys (renal dysfunction); marrow infiltration lowers red cell production (anemia); they cause osteolytic bone lesions or damage; and immune function is compromised, leading to a reduced ability to fight infections. The option listing hypercalcemia, renal dysfunction, anemia, bone damage, and reduced immune response aligns with these components.