Which of the following is a common clinical manifestation of Hodgkin's Lymphoma?

• A. Firm, painless enlarged lymph nodes
• B. Fever and night sweats
• C. Abdominal pain
• D. Headache

Answer: (A)

Painless, firm lymph node enlargement is the hallmark presentation of Hodgkin lymphoma. The disease oftenstarts with swollen nodes, frequently in the neck or supraclavicular region, that feel rubbery, are non-tender, and moveable. This nodal involvement reflects the malignant process within the lymphatic system and is the most common initial sign seen in many patients.

Fever and night sweats, while important and classified as B symptoms, can occur with Hodgkin lymphoma but are not the most typical presenting feature; they tend to appear as the disease progresses or with systemic activity. Abdominal pain and headache are not common presenting manifestations unless the disease involves those specific areas later on, which is less characteristic at initial presentation.

So, the best answer is the painless, firm, enlarged lymph nodes, reflecting the typical early sign of Hodgkin lymphoma.