Which set of investigations best represents a typical lymphoma staging workup?

• A. Lymph node biopsy, CBC, electrolytes, and imaging such as CT or PET
• B. Only X-ray chest
• C. Only CBC
• D. Only imaging

Answer: (A)

Staging lymphoma accurately needs both tissue confirmation and assessment of disease spread. A lymph node biopsy provides the histology needed to confirm lymphoma, determine its subtype and grade, and guide treatment decisions. Along with that, a CBC and electrolyte panel establish baseline blood counts and metabolic status, which are essential for planning therapy and recognizing risks. Imaging with CT or PET-CT then maps the extent of nodal and extranodal involvement throughout the body, defining the stage from I to IV. This combination—tissue diagnosis plus lab work and comprehensive imaging—offers the most complete staging workup. Relying on only a chest X-ray, or only a single test like CBC or imaging, would miss either the definitive diagnosis or the full extent of disease.